Ephrin type-a receptor 10
WebAbstract The Eph receptors are the largest known family of receptor tyrosine kinases. Initially all of them were identified as orphan receptors without known ligands, and their specific functions were not well understood. During the past few years, a corresponding family of ligands has been identified, called the ephrins, and specific functions have now … Eph receptors (Ephs, after erythropoietin-producing human hepatocellular receptors) are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins). Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Eph receptors and their … See more Ephs can be divided into two subclasses, EphAs and EphBs (encoded by the genetic loci designated EPHA and EPHB respectively), based on sequence similarity and on their binding affinity for either the See more The extracellular domain of Eph receptors is composed of a highly conserved globular ephrin ligand-binding domain, a cysteine-rich region and two fibronectin type III domains. The cytoplasmic domain of Eph receptors is composed of a juxtamembrane … See more The Eph receptors were initially identified in 1987 following a search for tyrosine kinases with possible roles in cancer, earning their name from the erythropoietin-producing hepatocellular carcinoma cell line from which their cDNA was obtained. These … See more The ability of Ephs and ephrins to mediate a variety of cell-cell interactions places the Eph/ephrin system in an ideal position to regulate a variety of different biological processes during embryonic development. Bi-directional signaling Unlike most other … See more • Eph+Family+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more
Ephrin type-a receptor 10
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WebDec 12, 2024 · The subclass of Ephrin-type A receptors/Ephrin-type A (EphA/EphrinA) are implicated as regulators of insulin secretion 6. Eph receptors are the largest known family of receptor protein–tyrosine ... WebTarget Ephrin type-A receptor 2 (Homo sapiens (Human)) Ambit Biosciences Curated by ChEMBL. ... Epidermal growth factor receptor 12; Mast/stem cell growth factor receptor Kit 8; Receptor-type tyrosine-protein kinase FLT3 [K633Q] ...
WebEphrin type-A receptor 10 (EPHA10) has been implicated as a potential target for breast and prostate cancer therapy. However, its involvement in oral squamous cell carcinoma (OSCC) remains unclear. We demonstrated that EPHA10 supports in vivo tumor growth and lymphatic metastasis of OSCC cells. OSCC cell migration, epithelial mesenchymal ... WebEphrin-Eph signaling is based on the binding of ephrin molecules to their cognate ephrin receptors on the surface of adjacent cells. There are two families of ephrins: ephrin-A proteins (A1-A6), which bind to ephrin type-A receptors (EphA1-A10), and ephrin-B proteins (B1-B3), which bind to ephrin type-B receptors (EphB1-EphB6). EphA and …
WebThe ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps. They have also been implicated in pathway … WebLOC107706141 ephrin type-A receptor 10-like [] Gene ID: 107706141, updated on 13-Jun-2024. Summary Other designations. ephrin type-A receptor 10-like ...
WebMar 9, 2024 · Enables GPI-linked ephrin receptor activity and growth factor binding activity. Involved in several processes, including ephrin receptor signaling pathway; neuron development; and positive regulation of phosphatidylinositol 3-kinase activity. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus. Located in neuron …
WebHere, we demonstrate that the ephrin type-A receptor 2 (EphA2) is an oral epithelial cell PRR that binds to exposed β-glucans on the surface of the fungal pathogen … howes moving solutionsWebProtein-Ligand Binding and Molecular Recognition Database. Targets 384 . Tyrosine-protein kinase ABL1 15; Epidermal growth factor receptor 13; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 10; Mast/stem cell growth factor receptor Kit 8; Vascular endothelial growth factor receptor 2 8; Receptor-type tyrosine … howes mowerhowes neck quincyWebFeb 7, 2010 · General Function. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway … howes ndWebEphrin receptors (Ephs) are receptor tyrosine kinases (RTKs) implicated in tissue development and homeostasis, and they are aberrantly expressed in tumors. Here, immunohistochemical Eph type-A and -B expression in thymic epithelial tumors (TETs) was assessed and correlated with clinicopathological parameters. Tissue microarrays from 98 … howes noodlesWebFeb 7, 2010 · Transmembrane receptor protein tyrosine kinase activity. Specific Function. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as … howes natural healthWebFeb 7, 2010 · Qin H, Shi J, Noberini R, Pasquale EB, Song J: Crystal structure and NMR binding reveal that two small molecule antagonists target the high affinity ephrin-binding channel of the EphA4 receptor. J Biol Chem. 2008 Oct 24;283 (43):29473-84. doi: 10.1074/jbc.M804114200. Epub 2008 Aug 14. hideaway sofa table